Yes, that Cindy McCain; the wife of former Presidential hopeful Republican Senator John McCain. The NOH8 campaign is “photo project and silent protest…in direct response to the passage of Proposition 8 [in California].”

In a statement on their website, NOH8 made the following statement:
In the year since we've started the NOH8 Campaign, we've often been surprised at some of the different individuals who have approached us showing their support. Few, though, have surprised us more than Cindy McCain - the wife of Senator John McCain and mother to vocal marriage equality advocate Meghan McCain. The McCains are one of the most well-known Republican families in recent history, and for Mrs. McCain to have reached out to us to offer her support truly means a lot. Although we had worked with Meghan McCain before and were aware of her own position, we'd never really thought the cause might be something her mother would get behind. We have a huge amount of respect for both of these women for being brave enough to make it known they support equal marriage rights for all Americans.
I think this is fantastic! I’m so glad that Cindy McCain decided to do this, especially since her high-profile husband is opposed to marriage equality.
Thanks, Cindy!
~ Samantha